Research on Transdermal Penetration of Rotigotine Transdermal Patchng

Abstract

The transdermal penetration behavior of drugs is a core link in the research and development of transdermal drug delivery systems, and its efficiency directly affects the in vivo absorption and therapeutic effect of drugs. The selection and processing of skin have an important impact on studying the transdermal penetration behavior of drugs. This study aims to investigate the penetration characteristics of rotigotine transdermal patches in different animal skins (mouse, rat, nude mouse, and pig skin) through in vitro transdermal penetration experiments, and to explore the effect of freezing treatment on skin penetration performance. The results showed that the 24-hour cumulative penetration amount of rotigotine transdermal patch in mouse skin was significantly higher than that in rat and nude mouse skin, with no significant difference between rat and nude mouse skin. Freezing treatment had no significant effect on the penetration amount in rat and nude mouse skin, but significantly reduced the penetration amount in mouse and pig skin, and the penetration amount in pig skin gradually decreased with the extension of freezing time. Meanwhile, there were differences in the initial penetration time and steady-state permeation rate of the drug among different animal skins. The results of this study provide a reference for the selection of animal models, optimization of freezing treatment conditions, and construction of IVIVC models in in vitro penetration experiments of rotigotine transdermal patches.