The mechanism and effects of traditional Chinese medicine in treating diseases through the regulation of intestinal microbiota
DOI:
https://doi.org/10.62051/kg10ge49Keywords:
Traditional Chinese medicine; Gut microbiota; Short-chain fatty acids; Bile acid metabolism; Multi-target regulation.Abstract
Traditional Chinese Medicine (TCM) is a traditional medical system based on natural plants, animals and minerals, emphasizing holistic regulation and treating both symptoms and root causes. In recent years, the role of TCM in regulating the intestinal microbiota has become a research hotspot. By analyzing 80 articles, this paper summarizes the regulatory effects of 48 TCM single herbs or compound preparations on the intestinal microbiota, involving 67 target sites. Among them, core microbiota such as Lactobacillus, Bifidobacterium and Akkermansia are frequently regulated. Studies have shown that TCM improves host metabolism (such as diabetes and obesity) and repairs intestinal barrier function through short-chain fatty acids (SCFAs) and bile acid metabolism axis (FXR/TGR5). In addition, TCM has shown significant regulatory effects on the microbiota in digestive system diseases, neurological diseases and immune inflammatory diseases. However, current research has limitations such as the gap between animal models and clinical translation, insufficient research on the mechanism of compound preparations, and individual differences. Future research can further promote the development and modernization of TCM.
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