Advances In The Application Of Click Chemistry In The Research Of Targeted Therapeutic Drugs

Abstract

Click chemistry has become an important tool in the research of targeted therapeutic drugs due to its high efficiency, specificity and mild reaction conditions. Cancer, as one of the major diseases that endanger human health, urgently needs more accurate and efficient treatment methods. Traditional targeted therapeutic methods have the problems of poor selectivity and easy to cause serious side effects, while click chemistry significantly improves the specificity and effect of treatment by efficiently connecting drugs with targeting ligands (such as antibodies, peptides, small molecules, etc.). Especially in the development of antibody-drug conjugates (ADCs) and nanodrug delivery systems, click chemistry not only optimizes the synthesis process, but also improves the stable release of drugs at the tumor site and reduces systemic toxicity. In addition, nanocarriers constructed based on click chemistry can further improve the targeting and bioavailability of drugs and achieve more effective treatment. Although the application of click chemistry in vivo still faces challenges such as reaction conditions, biocompatibility and safety, with the development of bioorthogonal reaction systems and the continuous emergence of new reactions, the application potential of click chemistry in the targeted therapy field will continue to expand. In the future, click chemistry is expected to be combined with cutting-edge technologies such as nanomedicine, immunotherapy, and artificial intelligence-assisted drug design to promote personalized and precision medicine to a higher level.