Toxicokinetics and Molecular Targets of Herb-Drug Interactions
DOI:
https://doi.org/10.62051/83vvpg60Keywords:
Banaba; pyrrolizidine alkaloids; ginseng; Traditional Chinese Medicine.Abstract
This review focus on the impact of Chinese herbal medicine on most of the body systems in animals and humans. There are advantages and drawbacks in Traditional Chinese Medicines (TCMs), since different dosages and types of active ingredients in TCM could cause different extents of side effects and cure certain diseases at the same time. Common side-effects include liver and kidney damage, allergic reaction, increase the possibility of bleeding, and some might contain heavy metals such as lead and arsenic; some study also proven to cause central nervous system. Nevertheless, taking TCM with proper and precise dosage could indeed reduce stress, enhance sleeping quality, and balance the hormones to regulate women's menstrual cycle. In this paper, herbs used include Fuzi, aristolochic acid, Pyrrolizidine alkaloids, Banaba, and ginseng. These are the main herbs that will be discussed. their properties and side-effects will be explained and methods used to track how toxic is produced will be demonstrated. Overall, this review aims to identify the actual damage toxins in herbs have on the central nervous system and body systems, and mechanisms causing damage as well as risk management to control the dosage to ensure it reaches maximum benefits with the least side effects.
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